Neonatal overnutrition causes early alterations in the central response to peripheral ghrelin
نویسندگان
چکیده
منابع مشابه
Neonatal overnutrition causes early alterations in the central response to peripheral ghrelin
OBJECTIVE Excess nutrient supply and rapid weight gain during early life are risk factors for the development of obesity during adulthood. This metabolic malprogramming may be mediated by endocrine disturbances during critical periods of development. Ghrelin is a metabolic hormone secreted from the stomach that acts centrally to promote feeding behavior by binding to growth hormone secretagogue...
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15 صفحه اولDiet-induced obesity causes peripheral and central ghrelin resistance by promoting inflammation
Ghrelin, a stomach-derived orexigenic peptide, transmits starvation signals to the hypothalamus via the vagus afferent nerve. Peripheral administration of ghrelin does not induce food intake in high fat diet (HFD)-induced obese mice. We investigated whether this ghrelin resistance was caused by dysfunction of the vagus afferent pathway. Administration (s.c.) of ghrelin did not induce food intak...
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Background: Feeding behavior is regulated via a complex network which interacts through diverse signals from central and peripheral tissues. OBJECTIVES: The main purpose of the current study was to determine the role of central cannabinoidergic (CBergic) system on ghrelin-induced hypophagia in 3-h food deprived (FD3) neonatal chicken. METHODS: In experiment 1, chicks were ICV injected with cont...
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Metabolic disorders have seen an increased prevalence in recent years in developed as well as developing countries. While it is clear lifestyle choices and habits have contributed to this epidemic, mounting evidence suggests the nutritional milieu during critical stages of development in early life can "program" individuals to develop the metabolic syndrome later in life. Extensive epidemiologi...
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ژورنال
عنوان ژورنال: Molecular Metabolism
سال: 2015
ISSN: 2212-8778
DOI: 10.1016/j.molmet.2014.10.003